Cold Plasma Sub-D Reviews – Does It Deliver the Results?

Discover the Ultimate Cold Plasma Sub-D Review: Is it the Holy Grail for Skin Tightening? Uncover the Truth in Our In-Depth Analysis!

Author By Glozine Staff
Updated :Dec 27, 2023
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Aging is a natural process that every individual experiences – it’s an inevitable reality that leaves visible cues on our skin, especially in delicate areas such as the neck. Wrinkles, sagging, and the appearance of a double chin are common concerns associated with neck aging, causing individuals to search tirelessly for effective solutions. Research has shown that various factors, including environmental stressors and genetic predisposition, contribute to the acceleration of the neck aging process, emphasizing the need for specialized care for this area.

Neck skin is super thin because it has less oil glands, meaning it needs more moisture than the face, says Neda Mehr, M.D., a dermatologist and founder of Pure Dermatology Cosmetic and Hair Center in Newport Beach, California.

In response to these concerns, Perricone MD introduced a product called Cold Plasma Sub-D, an anti-aging neck cream. This cream promises to lift, tighten, firm, and sculpt the neck area while reducing the appearance of a double chin and sagging skin under the jawline. Although these claims raise skepticism – as no topical skincare product can ‘sculpt’ skin or eliminate a double chin – the true effectiveness of Cold Plasma Sub-D lies in its key ingredients and their role in skincare.

A detailed examination of the product formulation, customer reviews, and supporting research will offer more insight into whether Cold Plasma Sub-D truly delivers on its promises.

What Is Cold Plasma Sub-D Reviews?

Cold Plasma Sub-D

Cold Plasma Sub-D, a product from the renowned Perricone MD skincare line, is a unique neck cream lauded for its ‘revolutionary’ liquid crystal delivery system. This advanced technology is designed to allow the key ingredients to penetrate the skin more deeply and rapidly.

This cream purports to deliver a range of benefits that include: visible firming and toning of the skin, imparting a ‘chiseled’ appearance, soothing and brightening of dull, sagging skin, and a reduction in the appearance of ‘double chin’ and sagging skin under the jawline. Furthermore, it claims to improve the appearance of wrinkles and redundant skin on the neck.

Despite these impressive claims, it’s essential to note that they may be misleading. No topical skincare product can fully rectify sagging skin, a claim often associated with surgical procedures like facelifts. Reviews of Cold Plasma Sub-D vary, with some users reporting noticeable changes, while critics argue that the product falls short of its promises.

The efficacy of the cream largely hinges on its key ingredients and individual skin responses. As always, achieving genuine and lasting skincare results often encompasses a comprehensive routine, healthy living, and sometimes clinical intervention.

The Brand: Perricone MD

Cold Plasma Sub-D

Perricone MD is a holistic skincare and wellness brand that has been in operation for over two decades. At the helm of this innovative company is Dr. Nicholas Perricone, a world-renowned author, healthy aging expert, award-winning inventor, and board-certified dermatologist.

His ground-breaking research on chronic and sub-clinical inflammation as the cause of aging and disease led to the creation of Perricone MD’s distinctive Three-Tier Philosophy, which is a comprehensive approach to wellness encompassing diet, essential dietary supplements, and topical skincare solutions.

This brand is renowned for its relentless pursuit of innovation, commitment to excellence, and a firm belief in delivering targeted, perceptible results. Perricone MD prides itself on its extensive research and stubborn commitment to quality, aiming to unlock the science behind healthy-looking skin from both inside-out and outside-in.

The company offers targeted nutritional supplements and potent skincare formulations, all backed by powerful ingredients, cutting-edge research, and extensive clinical and consumer studies.

Perricone MD’s commitment goes beyond just skincare; it believes in beauty from the inside-out and outside-in, ensuring a holistic approach to promote healthy-looking skin and body.


Is The Perricone MD Worth The Money?

Cold Plasma Sub-D

Brand Logo

Given the high-quality ingredients, extensive scientific research, and positive customer testimonials featured on their website, it can be convincingly argued that Perricone MD products provide good value for money.

The brand is committed to delivering clinically proven, dermatologist-tested, carefully curated skincare solutions. While the price point may be higher than average, investing in Perricone MD could be a wise decision for those prioritizing skin health and seeking effective anti-aging solutions.

However, it’s always important to consider individual skincare needs, budget, and potential skin reactions when making such an investment.

Ingredients Analysis For Cold Plasma Sub-D

Cold Plasma Sub-D

Let’s dive deep into the analysis of the key ingredients in the Cold Plasma Sub-D skincare product. Glycolic Acid, the second highest concentration ingredient, is an alpha hydroxy acid (AHA) known for its exfoliating properties. However, for it to function effectively as an exfoliant, the pH of the formulation should be less than 4, as indicated in the study ‘The Effects of Topical L (+) Lactic Acid and Lactate Lotions on the Skin’ published in the Journal of the American Academy of Dermatology.

Next in the list is Dimethyl MEA, a compound linked to the B vitamin choline. It enhances skin firmness, improves facial muscle tone, and has anti-inflammatory effects, as per a study ‘The role of dimethylaminoethanol in cosmetic dermatology’ in the American Journal of Clinical Dermatology. However, the stability and efficacy of Dimethyl MEA are contingent on the product’s pH level being over 10.

Caffeine, another key ingredient, is a natural stimulant that causes vasoconstriction, leading to temporary skin tightening and firming effects. This is supported by the research ‘Caffeine’s mechanisms of action and its cosmetic use’ in the journal Skin Pharmacology and Physiology.

Thiotic acid, or Alpha-lipoic acid, is a potent antioxidant beneficial for skin health. Despite its potential benefits, its effectiveness is compromised in jar packaging due to air exposure, leading to its deterioration, as explained in the study ‘Alpha-lipoic acid as a biological antioxidant’ in the journal Free Radical Biology and Medicine.

Finally, the product contains several synthetic fragrance ingredients. Unlisted chemicals used in fragrances may be of concern, potentially causing skin irritation or containing carcinogenic agents, as highlighted in the report ‘Unpacking the Fragrance Industry: Policy Failures, the Trade Secret Myth and Public Health’ by Women’s Voices for the Earth.

Hence, while Cold Plasma Sub-D boasts many ingredients with potential skin benefits, the pH-dependent nature of Glycolic Acid and Dimethyl MEA, along with the jar packaging for Thiotic Acid, could limit their effectiveness. Also, the use of synthetic fragrances raises health and safety concerns, making it crucial for consumers to thoroughly evaluate the product before use.


What Are The Pros and Cons of Cold Plasma Sub-D


  • Highly researched ingredients: Cold Plasma Sub-D is formulated with scientifically studied ingredients such as Glycolic Acid, Dimethyl MEA, Caffeine, and Thiotic acid which are known for their beneficial effects on skin health, as we documented in our Olay Total Effects CC Cream reviews article on another product containing this ingredient..
  • Holistic skincare brand: Perricone MD has a reputation for high-quality, clinically tested skincare solutions guided by a comprehensive wellness philosophy.
  • Positive customer reviews: Several users report noticeable improvements in skin firmness, smoothness, and overall appearance after using the product.
  • Unique delivery system: The cream’s ‘revolutionary’ liquid crystal delivery system is designed to allow key ingredients to penetrate the skin more deeply and rapidly.


  • High price point: Despite the brand’s commitment to quality, the relatively high cost might be a deterrent for some users.
  • Potential side effects: Some ingredients, particularly the synthetic fragrance blend, may cause skin irritation or sensitivity in certain individuals.
  • Packaging and pH issues: The effectiveness of certain ingredients such as Thiotic Acid and Glycolic Acid may be compromised due to the product’s packaging and pH level.
  • Misleading claims: The product promises to deliver effects such as a ‘chiseled’ appearance and reduction in ‘double chin’ and sagging skin, which are usually associated with surgical procedures, raising skepticism about the brand’s promises.

How To Use Cold Plasma Sub-D?

Cold Plasma Sub-D

Cold Plasma Sub-D is straightforward to incorporate into your daily skincare routine. It should be applied twice a day, early in the morning and in the evening, for optimal results. Here’s how to use it:

  • Start with a clean, dry face.
  • Dispense a quarter-sized amount of Cold Plasma Sub-D onto your hands.
  • Gently spread the product on your chin, jawline, neck, and décolletage.
  • To ensure full absorption, massage the applied cream in circular motions.
  • Don’t forget to apply evenly on the back of your neck for uniform results.

By adhering to this routine, Cold Plasma Sub-D aims to address common signs of aging such as sagging skin, wrinkles, and fine lines, and restore a youthful appearance to your skin.

Side Effects

Potential side effects of Cold Plasma Sub-D may include skin irritation and sensitivity due to the synthetic fragrance blend. The jar packaging might cause the antioxidant thioctic acid to deteriorate over time, reducing its effectiveness. Lastly, its pH level prevents glycolic acid and dimethyl MEA from functioning optimally, possibly limiting their benefits.


The potential benefits of Cold Plasma Sub-D include:

Firming and Toning Benefits

The product claims to deliver noticeable firming and toning benefits, which can potentially enhance the appearance of the neck area.

Enhanced Appearance

One of the product claims is that it imparts a “chiseled” appearance to the neck area.

Soothing and Brightening

Cold Plasma Sub-D is claimed to help soothe and brighten dull, sagging skin, potentially improving the overall look and feel.

Reduction of Sagging and Double Chin Appearance

The cream claims to reduce the appearance of a “double chin” and sagging skin under the jawline, potentially enhancing facial contours.

Improvement of Wrinkles and Redundant Skin

The product boasts of the ability to improve the appearance of wrinkles and redundant skin on the neck, promoting smoother, younger-looking skin.

Potent Antioxidant

Thiotic acid, also known as alpha-lipoic acid, a key ingredient in Cold Plasma Sub-D, is a potent antioxidant that might help neutralize free radicals and prevent the activation of other pro-inflammatory chemicals.


The formula contains a decent amount of caffeine which, as a natural stimulant, can cause vasoconstriction (constriction of the blood vessels), potentially resulting in temporary tightening and firming of the skin.

It’s essential, however, to note that these are claimed benefits, and the product’s efficacy may vary from person to person. Some ingredients’ efficacy may also be compromised due to the product’s pH and packaging.

Pricing and Refund Policy

Cold Plasma Sub-D, a renowned skincare product, is priced differently depending on where it’s purchased. On the Perricone MD official website, a 2 fl oz bottle retails for USD 135. However, at, the product is offered as part of two different kits. The Face & Neck Firming Duo kit is priced at $49.95, while the more comprehensive Face, Eye & Neck System is available for $79.95.

The return policies also vary between the two sites. Perricone MD stipulates a return window of 14 days from the date of delivery. The item must be sent back with all original packaging, and adherence to their Returns Policy is mandatory. However, they do not take responsibility for goods lost in transit. On the other hand, offers a more lenient return policy, allowing customers to return products within 60 days of receipt for a full refund, excluding shipping and handling, if not completely satisfied.

Reviews: Customers POV

User reviews for the Cold Plasma Sub-D range from praiseworthy feedback to some not-so-favorable comments, nevertheless culminating in an impressive overall rating of 4.3 stars out of a possible 5, based on over 418 customer evaluations.

A significant portion of these reviews hail from satisfied customers who have attested to witnessing a noticeable improvement in the firmness and smoothness of their neck skin following consistent usage of the product.

Cold Plasma Sub-D

One of the Reviewer says-

“I now understand why Perricone is so generous with samples. The results are so immediate you get hooked! I had been using the neck cream with SPF30 and was so impressed but when I used the sample of this at night my neck looked even better. I love the texture and how smoothly and quickly it goes into my skin. I do struggle with the smell. It isn’t very strong but if you’re sensitive to smells like I am, you will notice it. I’ve been adding a few drops of the chia oil – which smells amazing – and that helps. The results I’ve seen are so good, that I’ll get nose plugs if I have to. My neck was a crepey mess and just over a week of use it looks so much better. I can’t wait to see the results in a month. I resisted this product for a while because it was so pricey but it’s worth every penny!” – Eliza, 45-54.

In contrast, there are several negative reviews for Cold Plasma Sub-D from customers who saw no results whatsoever.

For example, one review says, “I bought this product to hope that it will help but after using the cream for a month, I see no improvement on my chin, neck, and behind the neck plus the cream become flaky that drops like dandruff on my shoulder especially if I’m wearing a black blouse. Not happy.” – To



In conclusion, Perricone MD’s Cold Plasma Sub-D is a unique and innovative skincare solution, specifically aimed at addressing the common signs of neck aging. Despite the skepticism surrounding some of its claims, the product’s formulation is supported by extensive scientific research and customer testimonials. Its key ingredients – including Glycolic Acid, Dimethyl MEA, Caffeine, and Thiotic Acid – are renowned for their beneficial effects on skin health. Moreover, the brand’s holistic approach to skincare, coupled with its commitment to delivering clinically proven, high-quality products, underscores its credibility and reliability in the skincare market.

While it’s important to bear in mind the potential side effects and the fact that individual responses may vary, Cold Plasma Sub-D has garnered a significant number of positive user reviews, emphasizing improvements in skin firmness, smoothness, and overall appearance. In addition, the unique ‘revolutionary’ liquid crystal delivery system is designed to enhance the penetration and effectiveness of its key ingredients.

In light of these factors, Cold Plasma Sub-D appears to offer value for money, especially for those prioritizing skin health and seeking effective anti-aging solutions. Always remember, however, that achieving genuine and lasting skincare results often encompasses a comprehensive routine, healthy living, and sometimes clinical intervention. Although Cold Plasma Sub-D cannot replace surgical procedures, its potential benefits still make it a valuable addition to your skincare regimen.

Frequently Asked Questions (FAQs)

Q. What is Cold Plasma Sub-D?

A. Cold Plasma Sub-D is an anti-aging neck cream from Perricone MD that claims to firm, tighten, and sculpt the neck area while reducing the appearance of wrinkles and sagging skin.

Q. How does Cold Plasma Sub-D work?

A. Its advanced liquid crystal delivery system allows key ingredients like Glycolic Acid, Dimethyl MEA, Caffeine, and Thiotic Acid to penetrate the skin deeply and rapidly.

Q. Is Cold Plasma Sub-D suitable for all skin types?

A. Yes, it’s designed for anyone concerned about neck aging, but individual responses may vary.

Q. Does Cold Plasma Sub-D have any side effects?

A. Some users have reported skin irritation and sensitivity due to the synthetic fragrance blend in the product.

Q. How often should I use Cold Plasma Sub-D?

A. For optimal results, it’s recommended to apply this cream twice daily, in the morning and in the evening.

Q. Can Cold Plasma Sub-D replace surgical procedures?

A. No, while the cream may improve the appearance of the neck, it can’t fully rectify sagging skin or ‘double chin’ as surgical procedures can.

Q. What is the key to achieving genuine and long-lasting skincare results?

A. A comprehensive skincare routine, a healthy lifestyle, and sometimes clinical intervention are essential.

Q. Is the Cold Plasma Sub-D worth the investment?

A. While the price point is higher than average, the high-quality ingredients, extensive research, and positive reviews suggest that it provides good value for money.

Q. How does the Brand Perricone MD stand out in the skincare market?

A. Perricone MD is known for its holistic approach, innovative solutions, extensive research, and commitment to excellence in skincare and wellness.

Q. What are the potential benefits of Cold Plasma Sub-D?

A. The product claims to firm and tone the skin, improve the appearance of wrinkles, brighten and soothe the skin, and reduce the appearance of sagging under the jawline.

Where to Buy?

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Glozine avoids using tertiary references. We have strict sourcing guidelines and rely on peer-reviewed studies, academic researches from medical associations and institutions. To ensure the accuracy of articles in Glozine, you can read more about the editorial process here.

  1. Skin anti-aging strategies:
  2. Epidermal and dermal effects of topical lactic acid:
  3. Drug-Induced Nail Abnormalities:
  4. Oral Supplementation of Specific Collagen Peptides Has Beneficial Effects on Human Skin Physiology: A Double-Blind, Placebo-Controlled Study:
  5. Alpha-lipoic acid as a biological antioxidant:
  6. Unpacking the Fragrance Industry: Policy Failures, the Trade Secret Myth and Public Health:
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Average Customer Rating:5.0 / 5.0 
1 Customer Reviews

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    Jessy Galan December 13, 2023

    Delivers Remarkable Results!!!!

    I can attest to its incredible lifting effects. My neck and jawline have visibly tightened, leaving me thrilled with the results. This product is a bit pricey, but its effectiveness in reducing crepey skin on my decolletage area within a few weeks makes it worth. Perricone’s reputation for top-quality products holds true, and I’m genuinely pleased with the noticeable and quick changes this cream has brought about.


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